Dynamical Binding Modes Determine Agonistic and Antagonistic Ligand Effects in the Prostate-Specific G-Protein Coupled Receptor (PSGR)

We analysed the ligand-based activation mechanism of the prostate-specific G-protein coupled receptor (PSGR), which is an olfactory receptor that mediates cellular growth in prostate cancer cells. Furthermore, it is an olfactory receptor with a known chemically near identic antagonist/agonist pair,...

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Detalles Bibliográficos
Autores principales: Wolf, Steffen, Jovancevic, Nikolina, Gelis, Lian, Pietsch, Sebastian, Hatt, Hanns, Gerwert, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700038/
https://www.ncbi.nlm.nih.gov/pubmed/29167480
http://dx.doi.org/10.1038/s41598-017-16001-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700038/
https://www.ncbi.nlm.nih.gov/pubmed/29167480
http://dx.doi.org/10.1038/s41598-017-16001-4

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