Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1

Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an attractive cancer immunotherapeutic target owing to its role in promoting tumoral immune escape. However, drug development has been hindered by limited structural information. Here, we report the crystal structures of hIDO1 in complex with its substr...

Descripción completa

Detalles Bibliográficos
Autores principales: Lewis-Ballester, Ariel, Pham, Khoa N., Batabyal, Dipanwita, Karkashon, Shay, Bonanno, Jeffrey B., Poulos, Thomas L., Yeh, Syun-Ru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700043/
https://www.ncbi.nlm.nih.gov/pubmed/29167421
http://dx.doi.org/10.1038/s41467-017-01725-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700043/
https://www.ncbi.nlm.nih.gov/pubmed/29167421
http://dx.doi.org/10.1038/s41467-017-01725-8

Ejemplares similares