Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks

Two crystal structures of Japanin, an 18 kDa immune-modulatory lipocalin from the Brown Ear Tick (Rhipicephalus appendiculatus), have been determined at 2.2 and 2.4 Å resolution. In both crystal forms the protein is in complex with cholesterol, which sits in a closed pocket at the centre of the lipo...

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Detalles Bibliográficos
Autores principales: Roversi, Pietro, Johnson, Steven, Preston, Stephen G., Nunn, Miles A., Paesen, Guido C., Austyn, Jonathan M., Nuttall, Patricia A., Lea, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700055/
https://www.ncbi.nlm.nih.gov/pubmed/29167574
http://dx.doi.org/10.1038/s41598-017-16413-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700055/
https://www.ncbi.nlm.nih.gov/pubmed/29167574
http://dx.doi.org/10.1038/s41598-017-16413-2

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