Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release

Low pH-induced ligand release and receptor recycling are important steps for endocytosis. The transmembrane protein sortilin, a β-propeller containing endocytosis receptor, internalizes a diverse set of ligands with roles in cell differentiation and homeostasis. The molecular mechanisms of pH-mediat...

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Detalles Bibliográficos
Autores principales: Leloup, Nadia, Lössl, Philip, Meijer, Dimphna H., Brennich, Martha, Heck, Albert J. R., Thies-Weesie, Dominique M. E., Janssen, Bert J. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700061/
https://www.ncbi.nlm.nih.gov/pubmed/29167428
http://dx.doi.org/10.1038/s41467-017-01485-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700061/
https://www.ncbi.nlm.nih.gov/pubmed/29167428
http://dx.doi.org/10.1038/s41467-017-01485-5

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