Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry

The Polo kinase is a master regulator of mitosis and cytokinesis conserved from yeasts to humans. Polo is composed of an N-term kinase domain (KD) and a C-term polo-box domain (PBD), which regulates its subcellular localizations. The PBD and KD can interact and inhibit each other, and this reciproca...

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Detalles Bibliográficos
Autores principales: Kachaner, David, Garrido, Damien, Mehsen, Haytham, Normandin, Karine, Lavoie, Hugo, Archambault, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700101/
https://www.ncbi.nlm.nih.gov/pubmed/29167465
http://dx.doi.org/10.1038/s41467-017-01876-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700101/
https://www.ncbi.nlm.nih.gov/pubmed/29167465
http://dx.doi.org/10.1038/s41467-017-01876-8

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