Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening

In voltage-activated ion channels, voltage sensor (VSD) activation induces pore opening via VSD-pore coupling. Previous studies show that the pore in KCNQ1 channels opens when the VSD activates to both intermediate and fully activated states, resulting in the intermediate open (IO) and activated ope...

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Detalles Bibliográficos
Autores principales: Hou, Panpan, Eldstrom, Jodene, Shi, Jingyi, Zhong, Ling, McFarland, Kelli, Gao, Yuan, Fedida, David, Cui, Jianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700111/
https://www.ncbi.nlm.nih.gov/pubmed/29167462
http://dx.doi.org/10.1038/s41467-017-01911-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700111/
https://www.ncbi.nlm.nih.gov/pubmed/29167462
http://dx.doi.org/10.1038/s41467-017-01911-8

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