Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity

The transcription factor Nrf2 coordinates an adaptive response to chemical and oxidative stress characterised by the upregulated expression of cytoprotective target genes. In order to understand the mechanistic relevance of Nrf2 as a marker of drug-induced stress it is important to know if this adap...

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Detalles Bibliográficos
Autores principales: Forootan, Shiva S., Mutter, Fiona E., Kipar, Anja, Iwawaki, Takao, Francis, Ben, Goldring, Christopher E., Park, B. Kevin, Copple, Ian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700176/
https://www.ncbi.nlm.nih.gov/pubmed/29167567
http://dx.doi.org/10.1038/s41598-017-16491-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700176/
https://www.ncbi.nlm.nih.gov/pubmed/29167567
http://dx.doi.org/10.1038/s41598-017-16491-2

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