Gα(i) is required for carvedilol-induced β(1) adrenergic receptor β-arrestin biased signaling

The β(1) adrenergic receptor (β(1)AR) is recognized as a classical Gα(s)-coupled receptor. Agonist binding not only initiates G protein-mediated signaling but also signaling through the multifunctional adapter protein β-arrestin. Some βAR ligands, such as carvedilol, stimulate βAR signaling preferen...

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Detalles Bibliográficos
Autores principales: Wang, Jialu, Hanada, Kenji, Staus, Dean P., Makara, Michael A., Dahal, Giri Raj, Chen, Qiang, Ahles, Andrea, Engelhardt, Stefan, Rockman, Howard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700200/
https://www.ncbi.nlm.nih.gov/pubmed/29167435
http://dx.doi.org/10.1038/s41467-017-01855-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700200/
https://www.ncbi.nlm.nih.gov/pubmed/29167435
http://dx.doi.org/10.1038/s41467-017-01855-z

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