Lack of specificity of antibodies raised against CLN3, the lysosomal/endosomal transmembrane protein mutated in juvenile Batten disease

Juvenile CLN3 (Batten) disease, a fatal, childhood neurodegenerative disorder, results from mutations in the CLN3 gene encoding a lysosomal/endosomal transmembrane protein. The exact physiological function of CLN3 is still unknown and it is unclear how CLN3 mutations lead to selective neurodegenerat...

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Detalles Bibliográficos
Autores principales: Nelson, Tarah, Pearce, David A., Kovács, Attila D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700270/
https://www.ncbi.nlm.nih.gov/pubmed/29089465
http://dx.doi.org/10.1042/BSR20171229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700270/
https://www.ncbi.nlm.nih.gov/pubmed/29089465
http://dx.doi.org/10.1042/BSR20171229

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