Cargando…

Resveratrol increases nucleus pulposus matrix synthesis through activating the PI3K/Akt signaling pathway under mechanical compression in a disc organ culture

Disc nucleus pulposus (NP) matrix homeostasis is important for normal disc function. Mechanical overloading seriously decreases matrix synthesis and increases matrix degradation. The present study aims to investigate the effects of resveratrol on disc NP matrix homeostasis under a relatively high-ma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Xiaorui, Leng, Xiaoming, Zhao, Man, Wu, Mei, Chen, Amei, Hong, Guoju, Sun, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700294/ https://www.ncbi.nlm.nih.gov/pubmed/29074559 http://dx.doi.org/10.1042/BSR20171319

Ejemplares similares

Resveratrol enhances matrix biosynthesis of nucleus pulposus cells through activating autophagy via the PI3K/Akt pathway under oxidative damage
por: Gao, Jinlou, et al.
Publicado: (2018)

Role of PI3K/AKT Signaling Pathway in Nucleus Pulposus Cells
por: Xiao, Quan, et al.
Publicado: (2021)

Resveratrol inhibits IL-1β-mediated nucleus pulposus cell apoptosis through regulating the PI3K/Akt pathway
por: Jiang, Yanhai, et al.
Publicado: (2019)

The response of nucleus pulposus cell senescence to static and dynamic compressions in a disc organ culture
por: Shi, Jianmin, et al.
Publicado: (2018)

Resveratrol attenuates high glucose-induced nucleus pulposus cell apoptosis and senescence through activating the ROS-mediated PI3K/Akt pathway
por: Wang, Wenping, et al.
Publicado: (2018)

Resveratrol attenuates mechanical compression-induced nucleus pulposus cell apoptosis through regulating the ERK1/2 signaling pathway in a disc organ culture
por: Zhang, Zhiwen, et al.
Publicado: (2018)

Puerarin Relieved Compression-Induced Apoptosis and Mitochondrial Dysfunction in Human Nucleus Pulposus Mesenchymal Stem Cells via the PI3K/Akt Pathway
por: Huang, Donghua, et al.
Publicado: (2020)

Resveratrol attenuates inflammation environment-induced nucleus pulposus cell senescence in vitro
por: Li, Xiaoming, et al.
Publicado: (2019)

Icariin Prevents H(2)O(2)-Induced Apoptosis via the PI3K/Akt Pathway in Rat Nucleus Pulposus Intervertebral Disc Cells
por: Deng, Xiangyu, et al.
Publicado: (2017)

Protective effects of resveratrol on autologous nucleus pulposus model of radiculopathy
por: Lin, Bin, et al.
Publicado: (2016)

Senescence of Nucleus Pulposus Chondrocytes in Human Intervertebral Discs
por: Kim, Ki-Won, et al.
Publicado: (2008)

Proteomic Signature of Nucleus Pulposus in Fetal Intervertebral Disc
por: Rajasekaran, Shanmuganathan, et al.
Publicado: (2020)

USP15 promotes the apoptosis of degenerative nucleus pulposus cells by suppressing the PI3K/AKT signalling pathway
por: Yu, Bin, et al.
Publicado: (2020)

Acacetin Alleviates Inflammation and Matrix Degradation in Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration in vivo
por: Wang, Hao, et al.
Publicado: (2020)

Current Perspectives on Nucleus Pulposus Fibrosis in Disc Degeneration and Repair
por: Sun, Yi, et al.
Publicado: (2022)

Icariin Prevents IL-1β-Induced Apoptosis in Human Nucleus Pulposus via the PI3K/AKT Pathway
por: Deng, Xiangyu, et al.
Publicado: (2017)

Combined effect of 17β-estradiol and resveratrol against apoptosis induced by interleukin-1β in rat nucleus pulposus cells via PI3K/Akt/caspase-3 pathway
por: Yang, Si-Dong, et al.
Publicado: (2016)

Role of p38–MAPK pathway in the effects of high-magnitude compression on nucleus pulposus cell senescence in a disc perfusion culture
por: Pang, Lianglong, et al.
Publicado: (2017)

Melatonin Suppresses Apoptosis of Nucleus Pulposus Cells through Inhibiting Autophagy via the PI3K/Akt Pathway in a High-Glucose Culture
por: Li, Jian, et al.
Publicado: (2021)

TSG-6 inhibits IL-1β-induced inflammatory responses and extracellular matrix degradation in nucleus pulposus cells by activating the PI3K/Akt signaling pathway
por: Wu, Bing, et al.
Publicado: (2022)

The protective effects of PI3K/Akt pathway on human nucleus pulposus mesenchymal stem cells against hypoxia and nutrition deficiency
por: Tian, DaSheng, et al.
Publicado: (2020)

Baicalein alleviates TNF-α-induced apoptosis of human nucleus pulposus cells through PI3K/AKT signaling pathway
por: Liu, Yang, et al.
Publicado: (2023)

Polydatin suppresses nucleus pulposus cell senescence, promotes matrix homeostasis and attenuates intervertebral disc degeneration in rats
por: Wang, Jianle, et al.
Publicado: (2018)

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
por: Sakai, Daisuke, et al.
Publicado: (2012)

Changes in the Molecular Phenotype of Nucleus Pulposus Cells with Intervertebral Disc Aging
por: Tang, Xinyan, et al.
Publicado: (2012)

Characterisation of porous knitted titanium for replacement of intervertebral disc nucleus pulposus
por: Tendulkar, Gauri, et al.
Publicado: (2017)

Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration
por: Li, Zheng, et al.
Publicado: (2019)

Relationships Between Disc Degeneration and Autophagy Expression in Human Nucleus Pulposus
por: Quan, Meiling, et al.
Publicado: (2019)

Osteogenic protein-1 attenuates nucleus pulposus cell apoptosis through activating the PI3K/Akt/mTOR pathway in a hyperosmotic culture
por: Yang, Yan, et al.
Publicado: (2018)

Static compression down-regulates N-cadherin expression and facilitates loss of cell phenotype of nucleus pulposus cells in a disc perfusion culture
por: Zhou, Haibo, et al.
Publicado: (2018)

Nucleus pulposus cell senescence is alleviated by resveratrol through regulating the ROS/NF-κB pathway under high-magnitude compression
por: Jiang, Yanhai, et al.
Publicado: (2018)

The inflammatory cytokine TNF-α promotes the premature senescence of rat nucleus pulposus cells via the PI3K/Akt signaling pathway
por: Li, Pei, et al.
Publicado: (2017)

Cyclic Mechanical Stretch Ameliorates the Degeneration of Nucleus Pulposus Cells through Promoting the ITGA2/PI3K/AKT Signaling Pathway
por: Wang, Dandan, et al.
Publicado: (2021)

Bardoxolone Methyl Ameliorates Compression-Induced Oxidative Stress Damage of Nucleus Pulposus Cells and Intervertebral Disc Degeneration Ex Vivo
por: Tian, Yueyang, et al.
Publicado: (2022)

Regenerative and Immunogenic Characteristics of Cultured Nucleus Pulposus Cells from Human Cervical Intervertebral Discs
por: Stich, Stefan, et al.
Publicado: (2015)

Effect of Static Load on the Nucleus Pulposus of Rabbit Intervertebral Disc Motion Segment in an Organ Culture
por: Zhan, Jia-Wen, et al.
Publicado: (2016)

Effect of optimized collagenase digestion on isolated and cultured nucleus pulposus cells in degenerated intervertebral discs
por: Feng, Xu, et al.
Publicado: (2018)

CD24 identifies nucleus pulposus progenitors/notochordal cells for disc regeneration
por: Liu, Zhuochao, et al.
Publicado: (2018)

Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species
por: Sakai, Daisuke, et al.
Publicado: (2018)

Developing a novel functional disc emulator to investigate the nucleus pulposus replacement
por: Raheem, Hassan M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_n872flc9u6qb7umfjamoue0qe1