Meropenem-Vaborbactam Resistance Selection, Resistance Prevention, and Molecular Mechanisms in Mutants of KPC-Producing Klebsiella pneumoniae

Vaborbactam (formerly RPX7009) is a new β-lactamase inhibitor based on a cyclic boronic acid pharmacophore with potent inhibitory activity against Klebsiella pneumoniae carbapenemases (KPC). It has been developed in combination with meropenem. The objective of these studies was to identify the conce...

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Detalles Bibliográficos
Autores principales: Sun, Dongxu, Rubio-Aparicio, Debora, Nelson, Kirk, Dudley, Michael N., Lomovskaya, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700310/
https://www.ncbi.nlm.nih.gov/pubmed/29038260
http://dx.doi.org/10.1128/AAC.01694-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700310/
https://www.ncbi.nlm.nih.gov/pubmed/29038260
http://dx.doi.org/10.1128/AAC.01694-17

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