The mitochondrial metabolic reprogramming agent trimetazidine as an ‘exercise mimetic’ in cachectic C26‐bearing mice

BACKGROUND: Cancer cachexia is characterized by muscle depletion and exercise intolerance caused by an imbalance between protein synthesis and degradation and by impaired myogenesis. Myofibre metabolic efficiency is crucial so as to assure optimal muscle function. Some drugs are able to reprogram ce...

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Detalles Bibliográficos
Autores principales: Molinari, Francesca, Pin, Fabrizio, Gorini, Stefania, Chiandotto, Sergio, Pontecorvo, Laura, Penna, Fabio, Rizzuto, Emanuele, Pisu, Simona, Musarò, Antonio, Costelli, Paola, Rosano, Giuseppe, Ferraro, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700442/
https://www.ncbi.nlm.nih.gov/pubmed/29130633
http://dx.doi.org/10.1002/jcsm.12226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700442/
https://www.ncbi.nlm.nih.gov/pubmed/29130633
http://dx.doi.org/10.1002/jcsm.12226

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