NAADP-evoked Ca(2+) signals through two-pore channel-1 require arginine residues in the first S4-S5 linker

Two-pore channels (TPCs) are two-domain members of the voltage-gated ion channel superfamily that localize to acidic organelles. Their mechanism of activation (ligands such as NAADP/PI(3,5)P(2) versus voltage) and ion selectivity (Ca(2+) versus Na(+)) is debated. Here we report that a cluster of arg...

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Detalles Bibliográficos
Autores principales: Patel, Sandip, Churamani, Dev, Brailoiu, Eugen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700777/
https://www.ncbi.nlm.nih.gov/pubmed/29129203
http://dx.doi.org/10.1016/j.ceca.2017.09.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700777/
https://www.ncbi.nlm.nih.gov/pubmed/29129203
http://dx.doi.org/10.1016/j.ceca.2017.09.003

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