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NAADP-evoked Ca(2+) signals through two-pore channel-1 require arginine residues in the first S4-S5 linker
Two-pore channels (TPCs) are two-domain members of the voltage-gated ion channel superfamily that localize to acidic organelles. Their mechanism of activation (ligands such as NAADP/PI(3,5)P(2) versus voltage) and ion selectivity (Ca(2+) versus Na(+)) is debated. Here we report that a cluster of arg...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700777/ https://www.ncbi.nlm.nih.gov/pubmed/29129203 http://dx.doi.org/10.1016/j.ceca.2017.09.003 |