Targeted Cell-to-Cell Delivery of Protein Payloads via the Granzyme-Perforin Pathway

There is great potential for engineering cellular therapeutics by repurposing biological systems. Here, we report utilization of the granzyme-perforin pathway of cytotoxic lymphocytes as a cell-to-cell protein delivery module. We designed and constructed granzyme B-derived chaperone molecules fused...

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Detalles Bibliográficos
Autores principales: Woodsworth, Daniel J., Dreolini, Lisa, Abraham, Libin, Holt, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700818/
https://www.ncbi.nlm.nih.gov/pubmed/29201936
http://dx.doi.org/10.1016/j.omtm.2017.10.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700818/
https://www.ncbi.nlm.nih.gov/pubmed/29201936
http://dx.doi.org/10.1016/j.omtm.2017.10.003

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