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R-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature
The formation of endothelial lumen is fundamental to angiogenesis and essential to the oxygenation of hypoxic tissues. The molecular mechanism underlying this important process remains obscure. Here, we show that Akt activation by a Ras homolog, R-Ras, stabilizes the microtubule cytoskeleton in endo...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700916/ https://www.ncbi.nlm.nih.gov/pubmed/29170374 http://dx.doi.org/10.1038/s41467-017-01865-x |