A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells

Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg) cells. The mouse parasite Heligmosomoides polygyrus can expand the host Treg population by secreting products that activate TGF-β signalling, but the...

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Detalles Bibliográficos
Autores principales: Johnston, Chris J. C., Smyth, Danielle J., Kodali, Ravindra B., White, Madeleine P. J., Harcus, Yvonne, Filbey, Kara J., Hewitson, James P., Hinck, Cynthia S., Ivens, Alasdair, Kemter, Andrea M., Kildemoes, Anna O., Le Bihan, Thierry, Soares, Dinesh C., Anderton, Stephen M., Brenn, Thomas, Wigmore, Stephen J., Woodcock, Hannah V., Chambers, Rachel C., Hinck, Andrew P., McSorley, Henry J., Maizels, Rick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701006/
https://www.ncbi.nlm.nih.gov/pubmed/29170498
http://dx.doi.org/10.1038/s41467-017-01886-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701006/
https://www.ncbi.nlm.nih.gov/pubmed/29170498
http://dx.doi.org/10.1038/s41467-017-01886-6

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