mTORC1 suppresses PIM3 expression via miR-33 encoded by the SREBP loci

The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth that is often aberrantly activated in cancer. However, mTORC1 inhibitors, such as rapamycin, have limited effectiveness as single agent cancer therapies, with feedback mechanisms inherent to the signaling ne...

Descripción completa

Detalles Bibliográficos
Autores principales: Kelsey, Ilana, Zbinden, Marie, Byles, Vanessa, Torrence, Margaret, Manning, Brendan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701013/
https://www.ncbi.nlm.nih.gov/pubmed/29170467
http://dx.doi.org/10.1038/s41598-017-16398-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701013/
https://www.ncbi.nlm.nih.gov/pubmed/29170467
http://dx.doi.org/10.1038/s41598-017-16398-y

Ejemplares similares