Towards personalised allele-specific CRISPR gene editing to treat autosomal dominant disorders

CRISPR/Cas9 holds immense potential to treat a range of genetic disorders. Allele-specific gene disruption induced by non-homologous end-joining (NHEJ) DNA repair offers a potential treatment option for autosomal dominant disease. Here, we successfully delivered a plasmid encoding S. pyogenes Cas9 a...

Descripción completa

Detalles Bibliográficos
Autores principales: Christie, Kathleen A., Courtney, David G., DeDionisio, Larry A., Shern, Connie Chao, De Majumdar, Shyamasree, Mairs, Laura C., Nesbit, M. Andrew, Moore, C. B. Tara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701044/
https://www.ncbi.nlm.nih.gov/pubmed/29170458
http://dx.doi.org/10.1038/s41598-017-16279-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701044/
https://www.ncbi.nlm.nih.gov/pubmed/29170458
http://dx.doi.org/10.1038/s41598-017-16279-4

Ejemplares similares