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Towards personalised allele-specific CRISPR gene editing to treat autosomal dominant disorders

CRISPR/Cas9 holds immense potential to treat a range of genetic disorders. Allele-specific gene disruption induced by non-homologous end-joining (NHEJ) DNA repair offers a potential treatment option for autosomal dominant disease. Here, we successfully delivered a plasmid encoding S. pyogenes Cas9 a...

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Detalles Bibliográficos
Autores principales:	Christie, Kathleen A., Courtney, David G., DeDionisio, Larry A., Shern, Connie Chao, De Majumdar, Shyamasree, Mairs, Laura C., Nesbit, M. Andrew, Moore, C. B. Tara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701044/ https://www.ncbi.nlm.nih.gov/pubmed/29170458 http://dx.doi.org/10.1038/s41598-017-16279-4

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