The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation

Polo-like kinase-1 (PLK1) plays a major role in driving mitotic events, including centrosome disjunction and separation, and is frequently over-expressed in human cancers. PLK1 inhibition is a promising therapeutic strategy and works by arresting cells in mitosis due to monopolar spindles. The p53 t...

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Detalles Bibliográficos
Autores principales: Smith, Linda, Farzan, Raed, Ali, Simak, Buluwela, Laki, Saurin, Adrian T., Meek, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701047/
https://www.ncbi.nlm.nih.gov/pubmed/29170437
http://dx.doi.org/10.1038/s41598-017-16394-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701047/
https://www.ncbi.nlm.nih.gov/pubmed/29170437
http://dx.doi.org/10.1038/s41598-017-16394-2

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