Receptor-binding loops in alphacoronavirus adaptation and evolution

RNA viruses are characterized by a high mutation rate, a buffer against environmental change. Nevertheless, the means by which random mutation improves viral fitness is not well characterized. Here we report the X-ray crystal structure of the receptor-binding domain (RBD) of the human coronavirus, H...

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Detalles Bibliográficos
Autores principales: Wong, Alan H. M., Tomlinson, Aidan C. A., Zhou, Dongxia, Satkunarajah, Malathy, Chen, Kevin, Sharon, Chetna, Desforges, Marc, Talbot, Pierre J., Rini, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701055/
https://www.ncbi.nlm.nih.gov/pubmed/29170370
http://dx.doi.org/10.1038/s41467-017-01706-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701055/
https://www.ncbi.nlm.nih.gov/pubmed/29170370
http://dx.doi.org/10.1038/s41467-017-01706-x

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