Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling

Mutations in PIK3CA are very frequent in cancer and lead to sustained PI3K pathway activation. The impact of acute expression of mutant PIK3CA during early stages of malignancy is unknown. Using a mouse model to activate the Pik3ca (H1047R) hotspot mutation in the heterozygous state from its endogen...

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Detalles Bibliográficos
Autores principales: Berenjeno, Inma M., Piñeiro, Roberto, Castillo, Sandra D., Pearce, Wayne, McGranahan, Nicholas, Dewhurst, Sally M., Meniel, Valerie, Birkbak, Nicolai J., Lau, Evelyn, Sansregret, Laurent, Morelli, Daniele, Kanu, Nnennaya, Srinivas, Shankar, Graupera, Mariona, Parker, Victoria E. R., Montgomery, Karen G., Moniz, Larissa S., Scudamore, Cheryl L., Phillips, Wayne A., Semple, Robert K., Clarke, Alan, Swanton, Charles, Vanhaesebroeck, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701070/
https://www.ncbi.nlm.nih.gov/pubmed/29170395
http://dx.doi.org/10.1038/s41467-017-02002-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701070/
https://www.ncbi.nlm.nih.gov/pubmed/29170395
http://dx.doi.org/10.1038/s41467-017-02002-4

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