Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma

Following peripheral axon injury, dysregulation of non-coding microRNAs (miRs) occurs in dorsal root ganglia (DRG) sensory neurons. Here we show that DRG neuron cell bodies release extracellular vesicles, including exosomes containing miRs, upon activity. We demonstrate that miR-21-5p is released in...

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Detalles Bibliográficos
Autores principales: Simeoli, Raffaele, Montague, Karli, Jones, Hefin R., Castaldi, Laura, Chambers, David, Kelleher, Jayne H., Vacca, Valentina, Pitcher, Thomas, Grist, John, Al-Ahdal, Hadil, Wong, Liang-Fong, Perretti, Mauro, Lai, Johnathan, Mouritzen, Peter, Heppenstall, Paul, Malcangio, Marzia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701122/
https://www.ncbi.nlm.nih.gov/pubmed/29176651
http://dx.doi.org/10.1038/s41467-017-01841-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701122/
https://www.ncbi.nlm.nih.gov/pubmed/29176651
http://dx.doi.org/10.1038/s41467-017-01841-5

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