Regulatory T cells control toxicity in a humanized model of IL-2 therapy

While patient selection and clinical management have reduced high-dose IL-2 (HDIL2) immunotherapy toxicities, the immune mechanisms that underlie HDIL2-induced morbidity remain unclear. Here we show that dose-dependent morbidity and mortality of IL-2 immunotherapy can be modeled in human immune syst...

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Detalles Bibliográficos
Autores principales: Li, Yan, Strick-Marchand, Helene, Lim, Ai Ing, Ren, Jiazi, Masse-Ranson, Guillemette, Dan Li, Jouvion, Gregory, Rogge, Lars, Lucas, Sophie, Bin Li, Di Santo, James P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701141/
https://www.ncbi.nlm.nih.gov/pubmed/29176694
http://dx.doi.org/10.1038/s41467-017-01570-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701141/
https://www.ncbi.nlm.nih.gov/pubmed/29176694
http://dx.doi.org/10.1038/s41467-017-01570-9

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