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Regulatory T cells control toxicity in a humanized model of IL-2 therapy

While patient selection and clinical management have reduced high-dose IL-2 (HDIL2) immunotherapy toxicities, the immune mechanisms that underlie HDIL2-induced morbidity remain unclear. Here we show that dose-dependent morbidity and mortality of IL-2 immunotherapy can be modeled in human immune syst...

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Detalles Bibliográficos
Autores principales:	Li, Yan, Strick-Marchand, Helene, Lim, Ai Ing, Ren, Jiazi, Masse-Ranson, Guillemette, Dan Li, Jouvion, Gregory, Rogge, Lars, Lucas, Sophie, Bin Li, Di Santo, James P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701141/ https://www.ncbi.nlm.nih.gov/pubmed/29176694 http://dx.doi.org/10.1038/s41467-017-01570-9

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