Prognostic value of thyroid hormones in acute ischemic stroke – a meta analysis
Previous studies on the association between thyroid hormones and prognosis of acute ischemic stroke (AIS) reported conflicting results. We conducted a meta-analysis to assess the prognostic value of thyroid hormones in AIS. The PubMed, EMBASE, and Cochrane library databases were searched through May...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701186/ https://www.ncbi.nlm.nih.gov/pubmed/29176727 http://dx.doi.org/10.1038/s41598-017-16564-2 |
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author | Jiang, Xingjun Xing, Hongyi Wu, Jing Du, Ruofei Liu, Houfu Chen, Jixiang Wang, Ji Wang, Chen Wu, Yan |
author_facet | Jiang, Xingjun Xing, Hongyi Wu, Jing Du, Ruofei Liu, Houfu Chen, Jixiang Wang, Ji Wang, Chen Wu, Yan |
author_sort | Jiang, Xingjun |
collection | PubMed |
description | Previous studies on the association between thyroid hormones and prognosis of acute ischemic stroke (AIS) reported conflicting results. We conducted a meta-analysis to assess the prognostic value of thyroid hormones in AIS. The PubMed, EMBASE, and Cochrane library databases were searched through May 12, 2017 to identify eligible studies on this subject. Out of 2,181 studies retrieved, 11 studies were finally included with a total number of 3,936 acute stroke patients for analysis. Odds ratio (OR) for predicting poor outcome or standardized mean difference (SMD) of thyroid hormone levels with 95% confidence intervals (95% CI) obtained from the studies were pooled using Review Manager 5.3. From the results, in AIS, patients with a poor outcome had lower levels of triiodothyronine (T3) and higher thyroxine (T4). Pooled OR confirmed the same association. Our study provides statistical evidence supporting the utility of thyroid hormone levels in prognosis of acute stroke. |
format | Online Article Text |
id | pubmed-5701186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57011862017-11-30 Prognostic value of thyroid hormones in acute ischemic stroke – a meta analysis Jiang, Xingjun Xing, Hongyi Wu, Jing Du, Ruofei Liu, Houfu Chen, Jixiang Wang, Ji Wang, Chen Wu, Yan Sci Rep Article Previous studies on the association between thyroid hormones and prognosis of acute ischemic stroke (AIS) reported conflicting results. We conducted a meta-analysis to assess the prognostic value of thyroid hormones in AIS. The PubMed, EMBASE, and Cochrane library databases were searched through May 12, 2017 to identify eligible studies on this subject. Out of 2,181 studies retrieved, 11 studies were finally included with a total number of 3,936 acute stroke patients for analysis. Odds ratio (OR) for predicting poor outcome or standardized mean difference (SMD) of thyroid hormone levels with 95% confidence intervals (95% CI) obtained from the studies were pooled using Review Manager 5.3. From the results, in AIS, patients with a poor outcome had lower levels of triiodothyronine (T3) and higher thyroxine (T4). Pooled OR confirmed the same association. Our study provides statistical evidence supporting the utility of thyroid hormone levels in prognosis of acute stroke. Nature Publishing Group UK 2017-11-24 /pmc/articles/PMC5701186/ /pubmed/29176727 http://dx.doi.org/10.1038/s41598-017-16564-2 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Jiang, Xingjun Xing, Hongyi Wu, Jing Du, Ruofei Liu, Houfu Chen, Jixiang Wang, Ji Wang, Chen Wu, Yan Prognostic value of thyroid hormones in acute ischemic stroke – a meta analysis |
title | Prognostic value of thyroid hormones in acute ischemic stroke – a meta analysis |
title_full | Prognostic value of thyroid hormones in acute ischemic stroke – a meta analysis |
title_fullStr | Prognostic value of thyroid hormones in acute ischemic stroke – a meta analysis |
title_full_unstemmed | Prognostic value of thyroid hormones in acute ischemic stroke – a meta analysis |
title_short | Prognostic value of thyroid hormones in acute ischemic stroke – a meta analysis |
title_sort | prognostic value of thyroid hormones in acute ischemic stroke – a meta analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701186/ https://www.ncbi.nlm.nih.gov/pubmed/29176727 http://dx.doi.org/10.1038/s41598-017-16564-2 |
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