Clinical and metabolic consequences of L-serine supplementation in hereditary sensory and autonomic neuropathy type 1C

Hereditary sensory neuropathy type 1 (HSAN1) may be the first genetic neuropathy amenable to a specific mechanism-based treatment, as L-serine supplementation can be used to lower the neurotoxic levels of 1-deoxysphingolipids (1-deoxySL) that cause the neurodegeneration. The treatment is so far unte...

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Detalles Bibliográficos
Autores principales: Auranen, Mari, Toppila, Jussi, Suriyanarayanan, Saranya, Lone, Museer A., Paetau, Anders, Tyynismaa, Henna, Hornemann, Thorsten, Ylikallio, Emil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701299/
https://www.ncbi.nlm.nih.gov/pubmed/29042446
http://dx.doi.org/10.1101/mcs.a002212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701299/
https://www.ncbi.nlm.nih.gov/pubmed/29042446
http://dx.doi.org/10.1101/mcs.a002212

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