CRISPR/Cas9-mediated targeted chromosome elimination

BACKGROUND: The CRISPR/Cas9 system has become an efficient gene editing method for generating cells carrying precise gene mutations, including the rearrangement and deletion of chromosomal segments. However, whether an entire chromosome could be eliminated by this technology is still unknown. RESULT...

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Detalles Bibliográficos
Autores principales: Zuo, Erwei, Huo, Xiaona, Yao, Xuan, Hu, Xinde, Sun, Yidi, Yin, Jianhang, He, Bingbing, Wang, Xing, Shi, Linyu, Ping, Jie, Wei, Yu, Ying, Wenqin, Wei, Wei, Liu, Wenjia, Tang, Cheng, Li, Yixue, Hu, Jiazhi, Yang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701507/
https://www.ncbi.nlm.nih.gov/pubmed/29178945
http://dx.doi.org/10.1186/s13059-017-1354-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701507/
https://www.ncbi.nlm.nih.gov/pubmed/29178945
http://dx.doi.org/10.1186/s13059-017-1354-4

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