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Pharmacodynamic testing and new validated HPLC method to assess the interchangeability between multi-source orlistat capsules
BACKGROUND: Orlistat is an irreversible inhibitor of the lipase enzyme that prevents trigylcerides from being digested, thereby inhibiting triglyceride hydrolysis and absorption. The resultant reduced calorie uptake enables a positive effect on weight control. Systemic absorption of the drug is, the...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701567/ https://www.ncbi.nlm.nih.gov/pubmed/29200824 http://dx.doi.org/10.2147/DDDT.S138926 |