Klebsazolicin inhibits 70S ribosome by obstruction of the peptide exit tunnel

While screening of small-molecular metabolites produced by most cultivatable microorganisms often results in rediscovery of known compounds, genome-mining programs allow to harness much greater chemical diversity and result in discovery of new molecular scaffolds. Here we report genome-guided identi...

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Detalles Bibliográficos
Autores principales: Metelev, Mikhail, Osterman, Ilya A., Ghilarov, Dmitry, Khabibullina, Nelli F., Yakimov, Alexander, Shabalin, Konstantin, Utkina, Irina, Travin, Dmitry Y., Komarova, Ekaterina S., Serebryakova, Marina, Artamonova, Tatyana, Khodorkovskii, Mikhail, Konevega, Andrey L., Sergiev, Petr V., Severinov, Konstantin, Polikanov, Yury S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701663/
https://www.ncbi.nlm.nih.gov/pubmed/28846667
http://dx.doi.org/10.1038/nchembio.2462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701663/
https://www.ncbi.nlm.nih.gov/pubmed/28846667
http://dx.doi.org/10.1038/nchembio.2462

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