Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy

Chemotherapy-induced peripheral neuropathy (CIPN) arises from collateral damage to peripheral afferent sensory neurons by anticancer pharmacotherapy, leading to debilitating neuropathic pain. No effective treatment for CIPN exists, short of dose-reduction which worsens cancer prognosis. Here, we rep...

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Detalles Bibliográficos
Autores principales: LoCoco, Peter M, Risinger, April L, Smith, Hudson R, Chavera, Teresa S, Berg, Kelly A, Clarke, William P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701795/
https://www.ncbi.nlm.nih.gov/pubmed/29125463
http://dx.doi.org/10.7554/eLife.29626

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701795/
https://www.ncbi.nlm.nih.gov/pubmed/29125463
http://dx.doi.org/10.7554/eLife.29626

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