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Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) arises from collateral damage to peripheral afferent sensory neurons by anticancer pharmacotherapy, leading to debilitating neuropathic pain. No effective treatment for CIPN exists, short of dose-reduction which worsens cancer prognosis. Here, we rep...
Autores principales: | LoCoco, Peter M, Risinger, April L, Smith, Hudson R, Chavera, Teresa S, Berg, Kelly A, Clarke, William P |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701795/ https://www.ncbi.nlm.nih.gov/pubmed/29125463 http://dx.doi.org/10.7554/eLife.29626 |
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