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Cohort-specific imputation of gene expression improves prediction of warfarin dose for African Americans
BACKGROUND: Genome-wide association studies are useful for discovering genotype–phenotype associations but are limited because they require large cohorts to identify a signal, which can be population-specific. Mapping genetic variation to genes improves power and allows the effects of both protein-c...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702158/ https://www.ncbi.nlm.nih.gov/pubmed/29178968 http://dx.doi.org/10.1186/s13073-017-0495-0 |