Cohort-specific imputation of gene expression improves prediction of warfarin dose for African Americans

BACKGROUND: Genome-wide association studies are useful for discovering genotype–phenotype associations but are limited because they require large cohorts to identify a signal, which can be population-specific. Mapping genetic variation to genes improves power and allows the effects of both protein-c...

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Detalles Bibliográficos
Autores principales: Gottlieb, Assaf, Daneshjou, Roxana, DeGorter, Marianne, Bourgeois, Stephane, Svensson, Peter J., Wadelius, Mia, Deloukas, Panos, Montgomery, Stephen B., Altman, Russ B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702158/
https://www.ncbi.nlm.nih.gov/pubmed/29178968
http://dx.doi.org/10.1186/s13073-017-0495-0

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