Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-κB signaling in an IL-6-dependent manner

BACKGROUND: Spinal cord astrocyte swelling is an important component to spinal cord edema and is associated with poor functional recovery as well as therapeutic resistance after spinal cord injury (SCI). High mobility group box-1 (HMGB1) is a mediator of inflammatory responses in the central nervous...

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Detalles Bibliográficos
Autores principales: Sun, Lin, Li, Man, Ma, Xun, Feng, Haoyu, Song, Junlai, Lv, Cong, He, Yajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702193/
https://www.ncbi.nlm.nih.gov/pubmed/29178911
http://dx.doi.org/10.1186/s12974-017-1008-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702193/
https://www.ncbi.nlm.nih.gov/pubmed/29178911
http://dx.doi.org/10.1186/s12974-017-1008-1

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