Atrial ERK1/2 activation in the embryo leads to incomplete Septal closure: a novel mouse model of atrial Septal defect

BACKGROUND: MEK1 mutation and activated MAPK signaling has been found in patients with RASopathies and abnormal cardiac development. Previous studies have suggested that regulation of fetal MAPK signaling is essential for normal cardiac development. We investigated the effect of active MEK1 overexpr...

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Detalles Bibliográficos
Autores principales: Yeh, Che-Chung, Fan, Yanying, Yang, Yi-Lin, Mann, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702213/
https://www.ncbi.nlm.nih.gov/pubmed/29178881
http://dx.doi.org/10.1186/s12929-017-0392-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702213/
https://www.ncbi.nlm.nih.gov/pubmed/29178881
http://dx.doi.org/10.1186/s12929-017-0392-2

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