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An Msh3 ATPase domain mutation has no effect on MMR function
OBJECTIVE: To demonstrate that the Msh3 ATPase domain is required for DNA mismatch repair and tumor suppression in a murine model. RESULTS: The DNA mismatch repair proteins are members of the ABC family of ATPases. ATP binding and hydrolysis regulates their mismatch repair function. In the current s...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702223/ https://www.ncbi.nlm.nih.gov/pubmed/29178930 http://dx.doi.org/10.1186/s13104-017-2939-4 |