Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications

Glioblastoma multiforme (GBM) is the most hostile type of brain cancer. Its aggressiveness is due to increased invasion, migration, proliferation, angiogenesis, and a decreased apoptosis. In this review, we discuss the role of key regulators of apoptosis in GBM and glioblastoma stem cells. Given the...

Descripción completa

Detalles Bibliográficos
Autores principales: Valdés-Rives, Silvia Anahi, Casique-Aguirre, Diana, Germán-Castelán, Liliana, Velasco-Velázquez, Marco A., González-Arenas, Aliesha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702396/
https://www.ncbi.nlm.nih.gov/pubmed/29259986
http://dx.doi.org/10.1155/2017/7403747
Descripción
Sumario:Glioblastoma multiforme (GBM) is the most hostile type of brain cancer. Its aggressiveness is due to increased invasion, migration, proliferation, angiogenesis, and a decreased apoptosis. In this review, we discuss the role of key regulators of apoptosis in GBM and glioblastoma stem cells. Given their importance in the etiology and pathogenesis of GBM, these signaling molecules may represent potential therapeutic targets.

Ejemplares similares