Differential Effects of Inhibitor Combinations on Lysophosphatidic Acid-Mediated Chemokine Secretion in Unprimed and Tumor Necrosis Factor-α-Primed Synovial Fibroblasts

Lysophosphatidic acid (LPA) is a pleiotropic bioactive lysophospholipid involved in inflammatory mediator synthesis. Signaling through p38MAPK, ERK, Rho kinase, and MSK-CREB contributes to LPA-mediated IL-8 production in fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients. The...

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Detalles Bibliográficos
Autores principales: Hui, Weili, Zhao, Chenqi, Bourgoin, Sylvain G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702485/
https://www.ncbi.nlm.nih.gov/pubmed/29209219
http://dx.doi.org/10.3389/fphar.2017.00848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702485/
https://www.ncbi.nlm.nih.gov/pubmed/29209219
http://dx.doi.org/10.3389/fphar.2017.00848

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