Allosteric coupling from G protein to the agonist binding pocket in GPCRs

G protein-coupled receptors (GPCRs) remain the primary conduit by which cells detect environmental stimuli and communicate with each other(1). Upon activation by extracellular agonists, these seven transmembrane domain (7TM)-containing receptors interact with heterotrimeric G proteins to regulate do...

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Detalles Bibliográficos
Autores principales: DeVree, Brian T., Mahoney, Jacob P., Vélez-Ruiz, Gisselle A., Rasmussen, Soren G.F., Kuszak, Adam J., Edwald, Elin, Fung, Juan-Jose, Manglik, Aashish, Masureel, Matthieu, Du, Yang, Matt, Rachel A, Pardon, Els, Steyaert, Jan, Kobilka, Brian K., Sunahara, Roger K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702553/
https://www.ncbi.nlm.nih.gov/pubmed/27362234
http://dx.doi.org/10.1038/nature18324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702553/
https://www.ncbi.nlm.nih.gov/pubmed/27362234
http://dx.doi.org/10.1038/nature18324

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