Cargando…

Allosteric coupling from G protein to the agonist binding pocket in GPCRs

G protein-coupled receptors (GPCRs) remain the primary conduit by which cells detect environmental stimuli and communicate with each other(1). Upon activation by extracellular agonists, these seven transmembrane domain (7TM)-containing receptors interact with heterotrimeric G proteins to regulate do...

Descripción completa

Detalles Bibliográficos
Autores principales:	DeVree, Brian T., Mahoney, Jacob P., Vélez-Ruiz, Gisselle A., Rasmussen, Soren G.F., Kuszak, Adam J., Edwald, Elin, Fung, Juan-Jose, Manglik, Aashish, Masureel, Matthieu, Du, Yang, Matt, Rachel A, Pardon, Els, Steyaert, Jan, Kobilka, Brian K., Sunahara, Roger K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702553/ https://www.ncbi.nlm.nih.gov/pubmed/27362234 http://dx.doi.org/10.1038/nature18324

Ejemplares similares

Ligand-regulated oligomerization of β(2)-adrenoceptors in a model lipid bilayer
por: Fung, Juan José, et al.
Publicado: (2009)

Activation and allosteric modulation of a muscarinic acetylcholine receptor
por: Kruse, Andrew C., et al.
Publicado: (2013)

Crystal Structure of the β(2)Adrenergic Receptor-Gs protein complex
por: Rasmussen, Søren G.F., et al.
Publicado: (2011)

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor
por: Rasmussen, Søren G. F., et al.
Publicado: (2011)

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs
por: Hollingsworth, Scott A., et al.
Publicado: (2019)

Allosteric Nanobodies Reveal the Dynamic Range and Diverse Mechanisms of GPCR Activation
por: Staus, Dean P, et al.
Publicado: (2016)

Identification of GPCR-Interacting Cytosolic Proteins Using HDL Particles and Mass Spectrometry-Based Proteomic Approach
por: Chung, Ka Young, et al.
Publicado: (2013)

Constrained catecholamines gain β(2)AR selectivity through allosteric effects on pocket dynamics
por: Xu, Xinyu, et al.
Publicado: (2023)

Structural insights into binding specificity, efficacy and bias of a β(2)AR partial agonist
por: Masureel, Matthieu, et al.
Publicado: (2018)

Author Correction: Constrained catecholamines gain β(2)AR selectivity through allosteric effects on pocket dynamics
por: Xu, Xinyu, et al.
Publicado: (2023)

Allosteric Modulation of GPCRs of Class A by Cholesterol
por: Jakubík, Jan, et al.
Publicado: (2021)

Applications of molecular replacement to G protein-coupled receptors
por: Kruse, Andrew C., et al.
Publicado: (2013)

Crystal structure of the μ-opioid receptor bound to a morphinan antagonist
por: Manglik, Aashish, et al.
Publicado: (2012)

Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptor
por: Cai, Yingying, et al.
Publicado: (2017)

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor
por: Livingston, Kathryn E, et al.
Publicado: (2018)

Catalytic activation of β-arrestin by GPCRs
por: Eichel, Kelsie, et al.
Publicado: (2018)

Functional Consequences of GPCR Heterodimerization: GPCRs as Allosteric Modulators
por: Haack, Karla K.V., et al.
Publicado: (2011)

Structure of the δ-opioid receptor bound to naltrindole
por: Granier, Sébastien, et al.
Publicado: (2012)

Allosteric Theory: Taking Therapeutic Advantage of the Malleable Nature of GPCRs
por: Kenakin, Terry
Publicado: (2007)

The Impact of the Secondary Binding Pocket on the Pharmacology of Class A GPCRs
por: Egyed, Attila, et al.
Publicado: (2022)

Annotation of Allosteric Compounds to Enhance Bioactivity Modeling for Class A GPCRs
por: Burggraaff, Lindsey, et al.
Publicado: (2020)

Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin
por: Kahsai, Alem W., et al.
Publicado: (2023)

Diverse GPCRs exhibit conserved water networks for stabilization and activation
por: Venkatakrishnan, A. J., et al.
Publicado: (2019)

The allosterically modulated FFAR2 is transactivated by signals generated by other neutrophil GPCRs
por: Lind, Simon, et al.
Publicado: (2023)

An improved yeast surface display platform for the screening of nanobody immune libraries
por: Uchański, Tomasz, et al.
Publicado: (2019)

Structure and Function of an Irreversible Agonist-β(2) Adrenoceptor complex
por: Rosenbaum, Daniel M., et al.
Publicado: (2011)

Pharmacological Characterization of Purified Full-Length Dopamine Transporter from Drosophila melanogaster
por: Pugh, Ciara Frances, et al.
Publicado: (2022)

Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain
por: Wu, Arum, et al.
Publicado: (2023)

Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs
por: Ferruz, Noelia, et al.
Publicado: (2018)

Adrenaline-activated structure of the β(2)-adrenoceptor stabilized by an engineered nanobody
por: Ring, Aaron M., et al.
Publicado: (2013)

Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies
por: Leemans, Margaux, et al.
Publicado: (2020)

Structural insight to mutation effects uncover a common allosteric site in class C GPCRs
por: Harpsøe, Kasper, et al.
Publicado: (2017)

Small Molecule Tools to Study Cellular Target Engagement for the Intracellular Allosteric Binding Site of GPCRs
por: Huber, Max E., et al.
Publicado: (2022)

Predicting allosteric pockets in protein biological assemblages
por: Kumar, Ambuj, et al.
Publicado: (2023)

Current and future advances in fluorescence-based visualization of plant cell wall components and cell wall biosynthetic machineries
por: DeVree, Brian T, et al.
Publicado: (2021)

Author Correction: Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs
por: Ferruz, Noelia, et al.
Publicado: (2019)

A promising small molecule binding pocket in class B GPCRs: expanding potential for drug development
por: Xiao, Huan, et al.
Publicado: (2023)

Editorial: The Physiology and Pharmacology of Leucine-rich Repeat GPCRs
por: Arey, Brian J., et al.
Publicado: (2016)

Unraveling the Molecular Nexus between GPCRs, ERS, and EMT
por: Kumari, Niti, et al.
Publicado: (2021)

Development of an antibody fragment that stabilizes GPCR/G-protein complexes
por: Maeda, Shoji, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_c2h8oo002dqcbl5do6c85rklg7