The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1

Ubiquitin chains linked through lysine63 (K63) play a critical role in inflammatory signalling. Following ligand engagement of immune receptors, the RING E3 ligase TRAF6 builds K63-linked chains together with the heterodimeric E2 enzyme Ubc13-Uev1A. Dimerisation of the TRAF6 RING domain is essential...

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Detalles Bibliográficos
Autores principales: Middleton, Adam J., Budhidarmo, Rhesa, Das, Anubrita, Zhu, Jingyi, Foglizzo, Martina, Mace, Peter D., Day, Catherine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702613/
https://www.ncbi.nlm.nih.gov/pubmed/29176576
http://dx.doi.org/10.1038/s41467-017-01665-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702613/
https://www.ncbi.nlm.nih.gov/pubmed/29176576
http://dx.doi.org/10.1038/s41467-017-01665-3

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