Combining “Bottom‐up” and “Top‐down” Approaches to Assess the Impact of Food and Gastric pH on Pictilisib (GDC‐0941) Pharmacokinetics

Pictilisib, a weakly basic compound, is an orally administered, potent, and selective pan‐inhibitor of phosphatidylinositol 3‐kinases for oncology indications. To investigate the significance of high‐fat food and gastric pH on pictilisib pharmacokinetics (PK) and enable label recommendations, a dedi...

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Detalles Bibliográficos
Autores principales: Lu, Tong, Fraczkiewicz, Grazyna, Salphati, Laurent, Budha, Nageshwar, Dalziel, Gena, Smelick, Gillian S., Morrissey, Kari M., Davis, John D., Jin, Jin Y., Ware, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702897/
https://www.ncbi.nlm.nih.gov/pubmed/28748626
http://dx.doi.org/10.1002/psp4.12228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702897/
https://www.ncbi.nlm.nih.gov/pubmed/28748626
http://dx.doi.org/10.1002/psp4.12228

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