RNAi mechanisms in Huntington’s disease therapy: siRNA versus shRNA

Huntington’s Disease (HD) is a genetically dominant trinucleotide repeat disorder resulting from CAG repeats within the Huntingtin (HTT) gene exceeding a normal range (> 36 CAGs). Symptoms of the disease manifest in middle age and include chorea, dystonia, and cognitive decline. Typical latency f...

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Detalles Bibliográficos
Autores principales: Aguiar, Sebastian, van der Gaag, Bram, Cortese, Francesco Albert Bosco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702971/
https://www.ncbi.nlm.nih.gov/pubmed/29209494
http://dx.doi.org/10.1186/s40035-017-0101-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702971/
https://www.ncbi.nlm.nih.gov/pubmed/29209494
http://dx.doi.org/10.1186/s40035-017-0101-9

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