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RNAi mechanisms in Huntington’s disease therapy: siRNA versus shRNA
Huntington’s Disease (HD) is a genetically dominant trinucleotide repeat disorder resulting from CAG repeats within the Huntingtin (HTT) gene exceeding a normal range (> 36 CAGs). Symptoms of the disease manifest in middle age and include chorea, dystonia, and cognitive decline. Typical latency f...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702971/ https://www.ncbi.nlm.nih.gov/pubmed/29209494 http://dx.doi.org/10.1186/s40035-017-0101-9 |