Microtubule-targeting agents can sensitize cancer cells to ionizing radiation by an interphase-based mechanism

BACKGROUND: The cytotoxic effects of microtubule-targeting agents (MTAs) are often attributed to targeted effects on mitotic cells. In clinical practice, MTAs are combined with DNA-damaging agents such as ionizing radiation (IR) with the rationale that mitotic cells are highly sensitive to DNA damag...

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Detalles Bibliográficos
Autores principales: Markowitz, Daniel, Ha, Grace, Ruggieri, Rosamaria, Symons, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703169/
https://www.ncbi.nlm.nih.gov/pubmed/29200877
http://dx.doi.org/10.2147/OTT.S143096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703169/
https://www.ncbi.nlm.nih.gov/pubmed/29200877
http://dx.doi.org/10.2147/OTT.S143096

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