Cargando…
Microtubule-targeting agents can sensitize cancer cells to ionizing radiation by an interphase-based mechanism
BACKGROUND: The cytotoxic effects of microtubule-targeting agents (MTAs) are often attributed to targeted effects on mitotic cells. In clinical practice, MTAs are combined with DNA-damaging agents such as ionizing radiation (IR) with the rationale that mitotic cells are highly sensitive to DNA damag...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703169/ https://www.ncbi.nlm.nih.gov/pubmed/29200877 http://dx.doi.org/10.2147/OTT.S143096 |