An RNA structure-mediated, posttranscriptional model of human α-1-antitrypsin expression

Chronic obstructive pulmonary disease (COPD) affects over 65 million individuals worldwide, where α-1-antitrypsin deficiency is a major genetic cause of the disease. The α-1-antitrypsin gene, SERPINA1, expresses an exceptional number of mRNA isoforms generated entirely by alternative splicing in the...

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Detalles Bibliográficos
Autores principales: Corley, Meredith, Solem, Amanda, Phillips, Gabriela, Lackey, Lela, Ziehr, Benjamin, Vincent, Heather A., Mustoe, Anthony M., Ramos, Silvia B. V., Weeks, Kevin M., Moorman, Nathaniel J., Laederach, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2017
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703279/
https://www.ncbi.nlm.nih.gov/pubmed/29109288
http://dx.doi.org/10.1073/pnas.1706539114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703279/
https://www.ncbi.nlm.nih.gov/pubmed/29109288
http://dx.doi.org/10.1073/pnas.1706539114

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