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An RNA structure-mediated, posttranscriptional model of human α-1-antitrypsin expression

Chronic obstructive pulmonary disease (COPD) affects over 65 million individuals worldwide, where α-1-antitrypsin deficiency is a major genetic cause of the disease. The α-1-antitrypsin gene, SERPINA1, expresses an exceptional number of mRNA isoforms generated entirely by alternative splicing in the...

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Detalles Bibliográficos
Autores principales:	Corley, Meredith, Solem, Amanda, Phillips, Gabriela, Lackey, Lela, Ziehr, Benjamin, Vincent, Heather A., Mustoe, Anthony M., Ramos, Silvia B. V., Weeks, Kevin M., Moorman, Nathaniel J., Laederach, Alain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2017
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703279/ https://www.ncbi.nlm.nih.gov/pubmed/29109288 http://dx.doi.org/10.1073/pnas.1706539114

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